Yeyiphi imifanekiso esebenza ngakumbi ekufumaneni ukuphinda-phinda komhlaza weprostate kwi-biochemical: i-PET/CT okanye i-mpMRI?

Ngokwe-meta-analysis yakutshanje, i-positron emission tomography/computed tomography (PET/CT) kunye ne-multi-parameter magnetic resonance imaging (mpMRI) zibonelela ngamazinga afanayo okubona ukuphinda ubuye komhlaza we-prostate (PCa).

Abaphandi bafumanise ukuba i-prostate specific membrane antigen (PSMA) PET/CT yayinezinga lokufunyaniswa lilonke lama-69 ekhulwini lokuphinda kuvele umhlaza we-prostate, xa kuthelekiswa nama-70 ekhulwini kwi-mpMRI.

“Kwi [ukubuyela umva kwe-biochemical], zombini ezi ndlela ziyasebenza. Iziphumo zethu zibonisa ukuba akukho mahluko mkhulu kwi-DR iyonke (izinga lokubona) phakathi kweendlela ezimbini zokuthatha imifanekiso, kwaye i-mpMRI ixabisa kancinci ngelixa igcina i-DR efanayo,” wabhala umbhali-mbhali uL. Xu, onxulumene neSikolo sezonyango. IYunivesithi yaseHunan yezonyango zemveli zaseTshayina, eHunan, eTshayina kunye noogxa bakhe.

Ngokubuyela kwakhona kwe-PCa yasekuhlaleni, ababhali bophando baphawule ukuba i-DR On mpMRI yayiphezulu nge-10% (62% vs. 52%). Abaphandi bakwafumanise ukuba i-PSMA PET/CT ibonise ukuphucuka kwe-18% kwi-DR Xa ixilonga i-lymph node metastasis (50% kunye ne-32%, ngokulandelelana). Nangona kunjalo, akukho nanye kwezi ziphumo eyayibalulekile ngokwezibalo, batsho ababhali bophando.

Abaphandi bakholelwa ukuba uvakalelo oluphezulu kunye nokuchaneka kunokunika i-PSMA PET/CT ithuba lokulinganisa i-PCa kunye nokufumanisa izilonda ezincinci, kodwa bayavuma ukuba ukufumaneka kwendlela yingxaki. I-MRI ye-Multi-parameter inokuba luncedo ekuchongeni ukuphinda kwakhona kwe-PCa kwindawo kunye ne-PCa ebalulekileyo ngokwezonyango, kodwa ababhali bophando bayavuma ukuba ukungafani kwababukeli kunokuba yingxaki kwi-mpMRI.

Nangona kunjalo, iziphumo zizonke zohlalutyo lwe-meta zibonisa ukuba zombini ezi ndlela zinendima ekuchongeni i-PCa BCR, kwaye zikhomba kwizifundo ezizayo ezinokunika ukucaca ngakumbi kule nkalo.

UXu kunye noogxa bakhe bagxininise impembelelo enkulu yeziphumo zophando kwindlela yokusebenza kwezonyango. Babonise ukuba amandla okuxilonga afanayo e-PSMA PET/CT kunye ne-mpMRI abonisa ukusebenza kakuhle kwale ndlela zombini ekufumaneni i-BCR kwizigulane ze-PCa. Nangona kunjalo, bagxininise imfuneko yophando olongezelelekileyo ukuze kuvavanywe ukufikeleleka, ukufikeleleka, kunye nokusebenza kakuhle kwezi ndlela zokuthatha imifanekiso.

Xa bexoxa ngemida yolu phononongo, ababhali bavumile ukuba ubungakanani obuncinci besampulu yezigulana ezingama-290 bubangelwe kukugxila kwabo ekuhlalutyeni izifundo zokuthelekisa ukuze kufunyanwe i-BCR kumaqela afanayo ezigulana. Bakwaphakamisa nokuba kungenzeka ukuba iziphumo zibe nocalucalulo ngenxa yeenkqubo ezahlukeneyo zokujonga imifanekiso kunye neempawu zesigulana kuzo zonke izifundo ezintandathu abaziphononongileyo.

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Ngophuhliso lwetekhnoloji yemifanekiso yezonyango, kuvela iinkampani ezininzi ezinokubonelela ngeemveliso zemifanekiso, ezinje ngee-injectors kunye neesirinji.I-LnkMedIteknoloji yezonyango yenye yazo. Sibonelela ngepotifoliyo epheleleyo yeemveliso zoxilongo ezincedisayo:I-CT single injector，I-CT double head injector,Inaliti ye-MRIkwayeI-DSA injector yoxinzelelo oluphezuluZisebenza kakuhle neentlobo ngeentlobo zee-CT/MRI scanner ezifana ne-GE, iPhilips, iSiemens. Ngaphandle kwe-injector, sikwabonelela ngesirinji kunye netyhubhu esetyenziswa kwiintlobo ezahlukeneyo zee-injector eziquka iMedrad/Bayer, iMallinckrodt/Guerbet, iNemoto, iMedtron, neUlrich.
Nazi izinto esiziqinisayo: amaxesha okuhambisa ngokukhawuleza; Iziqinisekiso ezipheleleyo zokuqinisekiswa, iminyaka emininzi yamava okuthumela ngaphandle, inkqubo yokuhlolwa komgangatho ogqibeleleyo, iimveliso ezisebenzayo ngokupheleleyo, siyakwamkela ngokufudumeleyo umbuzo wakho.