Ngowuphi umfanekiso osebenza ngakumbi ukuFumana i-Biochemical Recurrence ye-Prostate Cancer: i-PET / CT okanye i-mpMRI?

Ngokutsho kohlalutyo lwe-meta yakutshanje, i-positron emission tomography / computed tomography (PET / CT) kunye ne-multi-parameter magnetic resonance imaging (mpMRI) ibonelela ngamazinga afanayo okufumanisa ukuxilongwa komhlaza we-prostate (PCa) ukuphindaphinda.

Abaphandi bafumanisa ukuba i-prostate specific membrane antigen (PSMA) i-PET / CT inezinga elipheleleyo lokufumanisa i-69 yepesenti yokuphindaphinda komhlaza we-prostate, xa kuthelekiswa neepesenti ze-70 ze-mpMRI.

"Ngenxa [ye-biochemical relapse], zombini iindlela zisebenza. Iziphumo zethu zibonisa ukuba akukho mmahluko omkhulu kwi-DR (izinga lokubona) phakathi kweendlela ezimbini zokucinga, kwaye i-mpMRI ineendleko eziphezulu ngelixa igcina i-DR efanayo, "ubhale umbhali-mbhali wesifundo u-L. Xu, ohambelana neSikole seMithi. Hunan University of Traditional Chinese Medicine, Hunan, China kunye noogxa.

Ukuphindaphinda kwe-PCa yendawo, ababhali bokufunda baqaphele ukuba i-DR On mpMRI yayiyi-10% ephezulu (62% vs. 52%). Abaphandi baye bafumanisa ukuba i-PSMA PET / CT ibonise ukuphuculwa kwe-18% kwi-DR Xa ukuxilongwa kwe-lymph node metastasis (50% kunye ne-32%, ngokulandelanayo). Nangona kunjalo, akukho nanye yeziphumo ezibalulekayo ngokwezibalo, ababhali bokufunda bathi.

Abaphandi bakholelwa ukuba uvakalelo oluphezulu kunye nolwazi oluthile lunokunika i-PSMA PET / CT inzuzo kwi-PCa staging kunye nokufumanisa izilonda ezincinci, kodwa ziyavuma ukuba ukufumaneka kwendlela ngumba. I-MRI ye-multi-parameter inokuba luncedo ekuxilongeni ukuphindaphinda kwendawo kunye ne-PCa ebalulekileyo yeklinikhi, kodwa ababhali bokufunda bayavuma ukuba i-interobserver heterogeneity ingaba ngumba nge-mpMRI.

Nangona kunjalo, iziphumo ezipheleleyo ze-meta-analysis zibonisa ukuba zombini iindlela zinendima ekuxilongeni i-PCa BCR, kwaye zikhomba kwizifundo ezizayo ezinokuthi zinike ukucaca ngakumbi kulo mbandela.

UXu kunye noogxa bakhe bagxininise impembelelo enkulu yeziphumo zophononongo ekusebenzeni kwezonyango. Baye babonisa ukuba ukulinganiswa kokuxilongwa kwe-PSMA PET / CT kunye ne-mpMRI kubonisa ukusebenza kweendlela zombini ekufumaneni i-BCR kwizigulane ze-PCa. Nangona kunjalo, bagxininise imfuneko yophando oluthe kratya lokuvavanya ukufikeleleka, ukufikeleleka, kunye nokuphumelela kweendleko zezi ndlela zokucinga.

Xa bexubusha imida yophononongo, ababhali bavuma ukuba ubungakanani besampulu encinci yezigulane ze-290 yayiyisiphumo sokugxila kwabo ekuhlalutyeni izifundo ezithelekisayo zokufumanisa i-BCR ngaphakathi kwamaqela ezigulane ezifanayo. Bakwaphakamise ukuba nokwenzeka kokuthambekela kwiziphumo ngenxa yeendlela ezahlukeneyo zokucinga kunye neempawu zesigulana kuzo zonke izifundo ezithandathu abazijongileyo.

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Ngophuhliso lwetekhnoloji yemifanekiso yezonyango, kuphuma iinkampani ezininzi ezinokubonelela ngeemveliso zokucinga, ezinjengee-injection kunye neesirinji.LnkMediteknoloji yezonyango yenye yazo. Sinikezela ngepotfoliyo epheleleyo yeemveliso ezincedisayo zokuxilonga:CT isitofu esisodwa,CT isitofu sentloko kabini,Isitofu seMRIkwayeIsitofu soxinzelelo oluphezulu lwe-DSA. Basebenza kakuhle kunye neentlobo ezahlukeneyo ze-CT / MRI scanner brand ezifana ne-GE, Philips, Siemens. Ngaphandle kwe-injector, sinikezela ngesirinji kunye ne-tube esetyenziswayo kwiimpawu ezahlukeneyo ze-injector ziquka i-Medrad / Bayer, i-Mallincrodt / i-Guerbet, i-Nemoto, i-Medtron, i-Ulrich.
Oku kulandelayo ngamandla ethu angundoqo: amaxesha okuhanjiswa ngokukhawuleza; Gqibezela iziqinisekiso zesatifikethi, iminyaka emininzi yamava okuthunyelwa ngaphandle, inkqubo yokuhlola umgangatho ogqibeleleyo, iimveliso ezisebenza ngokupheleleyo, siyawamkela ngokufudumeleyo umbuzo wakho.