Imifanekiso yezonyango ihlala inceda ekuxilongeni ngempumelelo kunye nokunyanga ukukhula komhlaza. Ngokukodwa, i-imaging magnetic resonance imaging (MRI) isetyenziswa ngokubanzi ngenxa yesisombululo sayo esiphezulu, ngakumbi ngee-agent ezichaseneyo.
Uphononongo olutsha olupapashwe kwijenali yeNzululwazi ePhakamileyo inika ingxelo malunga nearhente entsha yokuzisonga i-nanoscale enokuthi incede ukubona amathumba ngokweenkcukacha ngakumbi ngeMRI.
Yintoni umahlukoamajelo eendaba?
Imidiya yothelekiso (ekwabizwa ngokuba yimithombo yeendaba echaseneyo) ziikhemikhali ezitofwayo (okanye ezithatyathwe) kwizihlunu zabantu okanye kumalungu ukukhuthaza ukujongwa kwemifanekiso. La malungiselelo axinene okanye aphantsi kunethishu ejikelezileyo, enza umahluko osetyenziselwa ukubonisa imifanekiso kunye nezixhobo ezithile. Ngokomzekelo, amalungiselelo e-iodine, i-barium sulfate, njl. Itofwa kumthambo wegazi wesigulane ngesirinji echasene noxinzelelo oluphezulu.
Kwi-nanoscale, iimolekyuli ziyaqhubeka egazini ixesha elide kwaye zinokungena kumathumba aqinileyo ngaphandle kokwenza iindlela zokuthintela ukuzikhusela kwi-tumor. Uninzi lwee-molecular complexes ezisekelwe kwi-nanomolecules ziye zafundwa njengabathwali abanokubakho be-CA kwiithumba.
Ezi zixhobo ze-nanoscale (NCAs) kufuneka zisasazwe ngokufanelekileyo phakathi kwegazi kunye nezicubu zomdla ukunciphisa ingxolo yangasemva kunye nokufezekisa umlinganiselo ophezulu we-signal-to-noise ratio (S / N). Kwiindawo eziphezulu, i-NCA iyaqhubeka kwigazi ixesha elide, ngaloo ndlela inyusa umngcipheko we-fibrosis ebanzi ngenxa yokukhululwa kwe-gadolinium ions kwi-complex.
Ngelishwa, uninzi lweeNCA ezisetyenziswayo ngoku ziqulathe iindibano zeentlobo ezahlukeneyo zeemolekyuli. Ngaphantsi komda othile, ezi micelles okanye ii-aggregates zikholisa ukuhlukana, kwaye isiphumo sesi siganeko asicacanga.
Olu phando luphefumlelweyo kwi-self-folding nanoscale macromolecules ezingenayo i-dissociation thresholds ebalulekileyo. Ezi ziquka undoqo onamafutha kunye nomaleko wangaphandle onyibilikayo okwanqanda intshukumo yeeyunithi ezinyibilikayo kumphezulu woqhagamshelwano. Oku kunokuthi emva koko kube nefuthe kwiiparamitha zokuphumla kwemolekyuli kunye neminye imisebenzi enokuthi isetyenziswe ukuphucula unikezelo lwamachiza kunye neempawu ezithile kwi-vivo.
Imidiya yothelekiso idla ngokutofwa emzimbeni wesigulana ngokusebenzisa isitofu esinoxinzelelo oluphezulu.LnkMed, umenzi oyingcali ogxile kuphando kunye nophuhliso lwee-ejenti ezichasayo kunye nezinto ezisetyenziswayo ezixhasayo, uthengiseCT, I-MRI, kwayeDSAii-injection ekhaya nakwamanye amazwe kwaye ziye zamkelwa yimarike kumazwe amaninzi. Umzi-mveliso wethu unokubonelela ngayo yonke inkxasoizinto ezityiwayongoku idumile ezibhedlele. Umzi-mveliso wethu uneenkqubo ezingqongqo zokuhlola umgangatho wokuveliswa kweempahla, ukuhanjiswa ngokukhawuleza, kunye nenkonzo ebanzi nesebenzayo emva kokuthengisa. Bonke abasebenzi beLnkMedithemba lokuthatha inxaxheba ngakumbi kwishishini le-angiography kwixesha elizayo, ukuqhubeka nokudala iimveliso ezikumgangatho ophezulu kubathengi, kunye nokubonelela ngokunyamekela izigulane.
Uphando lubonisa ntoni?
Indlela entsha yaziswa kwi-NCA ephucula imeko yokuphumla kwe-longitudinal yeeprotons, ukuyivumela ukuba ivelise imifanekiso ebukhali kumthwalo ophantsi kakhulu we-gadolinium complexes. Ukulayishwa okuphantsi kunciphisa umngcipheko wemiphumo emibi kuba idosi ye-CA incinci.
Ngenxa yepropathi ezisongayo, i-SMDC enesiphumo inondoqo oxineneyo kunye nemekobume exineneyo. Oku kwandisa ukuyekelela njengoko intshukumo yangaphakathi kunye nenxalenye ejikeleze ujongano lwe-SMDC-Gd inokuthintelwa.
Le NCA inokuqokelela ngaphakathi kwamathumba, okwenza kube nokwenzeka ukuba usebenzise unyango lwe-Gd neutron ukubamba ukunyanga amathumba ngokuthe ngqo nangempumelelo. Ukuza kuthi ga ngoku, oku akukafezekiswa ngokweklinikhi ngenxa yokunqongophala kokukhetha ukuhambisa i-157Gd kwiithumba kwaye zigcinwe kwindawo efanelekileyo. Isidingo sokutofa iidosi eziphezulu sinxulunyaniswa neziphumo ezibi kunye neziphumo ezibi ngenxa yokuba isixa esikhulu se-gadolinium esijikeleze ithumba siyayikhusela kwi-neutron exposure.
I-nanoscale isekela ukuqokelelwa okukhethiweyo koxinzelelo lwezonyango kunye nokusasazwa ngokufanelekileyo kwamachiza ngaphakathi kwamathumba. Iimolekyuli ezincinci zinokuphuma kwii-capillaries, okukhokelela ekusebenzeni okuphezulu kwe-antitumor.
“Njengoko i-diameter ye-SMDC ingaphantsi kwe-10 nm, iziphumo zethu zinokuthi zivela ekungeneni okunzulu kwe-SMDC ibe ngamathumba, inceda ukubaleka impembelelo yokukhusela i-neutron eshushu kunye nokuqinisekisa ukusasazwa ngokufanelekileyo kwee-electron kunye nemitha ye-gamma emva kokubonakaliswa kwe-neutron ye-thermal.“
Lithini ifuthe?
"Inokuxhasa uphuhliso lwee-SMDCs eziphuculweyo zokuxilongwa kwe-tumor engcono, nokuba kufuneka iinaliti ezininzi ze-MRI."
"Iziphumo zethu ziqaqambisa amandla okulungisa i-NCA ngokuzisonga kwi-molekyuli kunye nokuphawula inkqubela phambili enkulu ekusebenziseni i-NCA ekuxilongweni komhlaza kunye nonyango."
Ixesha lokuposa: Dec-08-2023
