Imifanekiso yezonyango idla ngokunceda ekuxilongeni nasekunyangeni amaqhuma anomhlaza ngempumelelo. Ngokukodwa, i-magnetic resonance imaging (MRI) isetyenziswa kakhulu ngenxa yokuba inamandla aphezulu, ingakumbi xa isetyenziswa kwiiarhente zokwahlulahlula.
Uphononongo olutsha olupapashwe kwiphephancwadi i-Advanced Science lubika nge-arhente entsha yokwahlulahlula i-nanoscale egoqayo enokunceda ekuboniseni iithumba ngokweenkcukacha nge-MRI.
Yintoni umahlukoimidiya?
I-contrast media (ekwaziwa ngokuba yi-contrast media) ziikhemikhali ezifakwa (okanye ezithathwa) kwizicwili okanye kumalungu omzimba omntu ukuze kuphuculwe ukujonga umfanekiso. La malungiselelo axinene okanye angaphantsi kunezicubu ezijikelezileyo, nto leyo edala i-contrast esetyenziselwa ukubonisa imifanekiso ngezixhobo ezithile. Umzekelo, amalungiselelo e-iodine, i-barium sulfate, njl.njl. asetyenziswa rhoqo ukujonga i-X-ray. Ifakwa kwimithambo yegazi yesigulana ngesirinji ye-contrast enoxinzelelo oluphezulu.
Kwi-nanoscale, iimolekyuli zihlala egazini ixesha elide kwaye zinokungena kwii-tumor eziqinileyo ngaphandle kokubangela iindlela zokuzikhusela zomzimba ezithile kwi-tumor. Ii-complexes ezininzi ze-molecular ezisekelwe kwi-nanomolecules ziye zafundwa njengezithwala i-CA kwii-tumor.
Ezi nanoscale contrast agents (NCAs) kufuneka zisasazwe ngokufanelekileyo phakathi kwegazi kunye nezicubu ezinomdla ukunciphisa ingxolo yangasemva kunye nokufikelela kumlinganiselo ophezulu wesignali-kwingxolo (S/N). Xa kugxilwe kakhulu, i-NCA ihlala egazini ixesha elide, ngaloo ndlela inyusa umngcipheko we-fibrosis enkulu ngenxa yokukhululwa kwee-ion ze-gadolinium ezivela kwi-complex.
Ngelishwa, uninzi lwee-NCA ezisetyenziswayo ngoku ziqulathe iindibano zeentlobo ezahlukeneyo zeemolekyuli. Ngaphantsi komda othile, ezi micelles okanye ii-aggregates zithanda ukwahluka, kwaye isiphumo sale siganeko asicaci.
Olu phando luphembelele uphando malunga nee-macromolecules ezizisonga ngokwazo ezingenazo imingcele ebalulekileyo yokwahlukana. Ezi ziquka i-fatty core kunye nomaleko wangaphandle onyibilikayo othintela nokuhamba kweeyunithi ezinyibilikayo kumphezulu woqhagamshelwano. Oku kunokubangela iiparamitha zokuphumla kweemolekyuli kunye neminye imisebenzi enokuguqulwa ukuphucula ukuhanjiswa kwamayeza kunye neempawu ezithile emzimbeni.
I-contrast media idla ngokufakwa emzimbeni wesigulana nge-contrast injector enoxinzelelo oluphezulu.I-LnkMed, umenzi ochwephesha ogxile kuphando nophuhliso lwee-contrast agent injectors kunye nezinto ezisetyenziswayo ezixhasayo, uthengiseCT, I-MRIkunyeI-DSAii-injectors ekhaya nakwamanye amazwe kwaye ziye zaqatshelwa yimarike kumazwe amaninzi. Umzi-mveliso wethu unokubonelela ngazo zonke izinto ezixhasayoizinto ezisetyenziswayoithandwa kakhulu ngoku ezibhedlele. Umzi-mveliso wethu uneenkqubo ezingqongqo zokuhlola umgangatho wokwenziwa kweempahla, ukuhanjiswa ngokukhawuleza, kunye nenkonzo epheleleyo nesebenzayo emva kokuthengisa. Bonke abasebenzi baseI-LnkMedNdinethemba lokuba ndiza kuthatha inxaxheba ngakumbi kushishino lwe-angiography kwixesha elizayo, ndiqhubeke nokwenza iimveliso ezikumgangatho ophezulu kubathengi, kwaye ndibonelele ngononophelo kwizigulane.
Uphando lubonisa ntoni?
Indlela entsha ingeniswa kwi-NCA ephucula imeko yokuphumla kwe-longitudinal yeeproton, ivumela ukuba ivelise imifanekiso ebukhali xa imithwalo ephantsi kakhulu yee-gadolinium complexes ingena emzimbeni. Umthwalo omncinci unciphisa umngcipheko wemiphumo emibi kuba idosi ye-CA incinci.
Ngenxa yeempawu zokuzisonga, i-SMDC ephumayo inombindi oxineneyo kunye nendawo exineneyo exineneyo. Oku kwandisa ukukhululeka njengoko intshukumo yangaphakathi neyecandelo ejikeleze ujongano lwe-SMDC-Gd inokuthintelwa.
Le NCA inokuqokelelana ngaphakathi kweethumba, nto leyo eyenza kube nokwenzeka ukusebenzisa unyango lwe-Gd neutron capture ukunyanga iithumba ngokukodwa nangokufanelekileyo. Ukuza kuthi ga ngoku, oku akukafikelelwa ngokwezonyango ngenxa yokungabikho kokukhetha ukuhambisa i-157Gd kwiithumba kwaye zigcinwe kumanqanaba afanelekileyo. Imfuneko yokufaka iidosi eziphezulu inxulunyaniswa nemiphumo emibi kunye neziphumo ezimbi kuba inani elikhulu le-gadolinium elijikeleze ithumba liyikhusela ekuvezweni yi-neutron.
I-nanoscale ixhasa ukuqokelelana okukhethiweyo koxinzelelo lonyango kunye nokusasazwa ngokugqibeleleyo kwamayeza ngaphakathi kweethumba. Iimolekyuli ezincinci zinokuphuma kwii-capillaries, nto leyo ekhokelela kumsebenzi ophezulu wokulwa nethumba.
“Ngenxa yokuba ububanzi be-SMDC bungaphantsi kwe-10 nm, iziphumo zethu zinokwenzeka ukuba zivela ekungeneni nzulu kwe-SMDC kwiithumba, zinceda ekubalekeni isiphumo sokukhusela se-thermal neutrons kunye nokuqinisekisa ukusasazeka okusebenzayo kwee-electron kunye ne-gamma rays emva kokuvezwa kwe-thermal neutron.“
Iyintoni impembelelo?
"Ingaxhasa uphuhliso lwee-SMDCs ezilungiselelweyo ukuze kufunyanwe isifo esingcono, nokuba kufuneka i-MRI injections ezininzi."
“Iziphumo zethu zibonisa amandla okulungisa i-NCA ngoyilo lweemolekyuli ezizisonga ngokwazo kwaye ziphawula inkqubela phambili enkulu ekusetyenzisweni kwe-NCA ekuxilongweni nasekunyangweni komhlaza.”
Ixesha lokuthumela: Disemba-08-2023
