Ukuphucula Ukhathalelo Lwezigulane Ngokulungiswa Kokunciphisa Ubunzima Be-AI Kwimifanekiso Ye-PET

Uphononongo olutsha olunesihloko esithi “Using Pix-2-Pix GAN for Deep Learning-Based Whole-Body PSMA PET/CT Attenuation Correction” lupapashwe kutshanje kwiVolume 15 ye-Oncotarget ngoMeyi 7, 2024.

Ukuvezwa kwemitha evela kwizifundo ze-PET/CT ezilandelelanayo ekulandeleni izigulane ze-oncology kuyinkxalabo. Kolu phando lwakutshanje, iqela labaphandi eliquka uKevin C. Ma, uEsther Mena, uLiza Lindenberg, uNathan S. Lay, uPhillip Eclarinal, uDeborah E. Citrin, uPeter A. Pinto, uBradford J. Wood, uWilliam L. Dahut, uJames L. Gulley, uRavi A. Madan, uPeter L. Choyke, uIsmail Baris Turkbey, kunye noStephanie A. Harmon abavela kwiNational Cancer Institute kwiNational Institutes of Health bazise isixhobo sobuchule bokwenziwa (AI). Esi sixhobo sijolise ekuveliseni imifanekiso ye-attenuation-corrected PET (AC-PET) evela kwimifanekiso ye-non-attenuation-corrected PET (NAC-PET), enokunciphisa imfuneko ye-CT scans yedosi ephantsi.

"Imifanekiso yePET eyenziwe yi-Ai inamandla okunciphisa isidingo sokulungiswa kokunciphisa ukuvuvukala kwi-CT scans ngelixa igcina iimpawu zobungakanani kunye nomgangatho womfanekiso kwizigulane ezinomhlaza weprostate."

Iindlela: I-algorithm yokufunda ngokunzulu esekelwe kwi-2D Pix-2-Pix generative adversarial network (GAN) yaphuhliswa ngokusekelwe kwimifanekiso edibeneyo ye-AC-PET kunye ne-NAC-PET. Uphononongo lwe-18F-DCFPyL PSMA (i-Prostate-specific membrane antigen) lwe-PET-CT lwezigulane ezingama-302 ezinomhlaza we-prostate lwahlulwe lwaba ngamaqela oqeqesho, ukuqinisekiswa, kunye novavanyo (n 183, 60, kunye no-59, ngokulandelanayo). Imodeli yaqeqeshwa kusetyenziswa amaqhinga amabini amiselweyo: I-Standard Uptake Value (SUV) esekelwe kunye ne-SUV-NYUL esekelwe. Ukuskena ukusebenza okuthe tye kwavavanywa kusetyenziswa i-normalized mean square error (NMSE), i-mean absolute error (MAE), i-structural similarity index (SSIM) kunye ne-peak signal-to-noise ratio (PSNR). Ugqirha we-nuclear medicine wenza uhlalutyo lwenqanaba lesilonda kwindawo enomdla. Izalathisi ze-SUV zavavanywa kusetyenziswa i-intra-group correlation coefficient (ICC), i-repeatability coefficient (RC), kunye neemodeli ze-linear mixed effects.

Iziphumo：Kwiqela lovavanyo oluzimeleyo, i-NMSE, i-MAE, i-SSIM, kunye ne-PSNR ephakathi yayiyi-13.26%, i-3.59%, i-0.891, kunye ne-26.82, ngokulandelelana. I-ICC ye-SUVmax kunye ne-SUV mean yayiyi-0.88 kunye ne-0.89, nto leyo ebonisa ulwalamano oluqinileyo phakathi kweempawu zokuqala zemifanekiso yokulinganisa kunye ne-AI-generated. Izinto ezifana nendawo yezilonda, uxinano (iiyunithi zeHounsfield), kunye nokuthathwa kwezilonda kufunyenwe ukuba zichaphazela impazamo ehambelanayo kwiimetrikhi ze-SUV ezenziweyo (zonke i-p < 0.05).

"I-AC-PET eyenziwe yimodeli yePix-2-Pix GAN ibonisa imilinganiselo yeSUV ehambelana ngokusondeleyo nemifanekiso yokuqala. Imifanekiso yePET eyenziwe yi-AI ibonisa amandla eklinikhi athembisayo okunciphisa imfuneko ye-CT scans yokulungisa ukuncitshiswa kwe-attenuation ngelixa kugcinwa iimpawu zobungakanani kunye nomgangatho womfanekiso."

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Njengoko sonke sisazi, uphuhliso lweshishini lemifanekiso yezonyango alunakwahlulwa kuphuhliso lwezixhobo zonyango ezininzi - ii-contrast agent injectors kunye nezinto ezisetyenziswayo ezixhasayo - ezisetyenziswa kakhulu kweli candelo. E-China, edume ngeshishini layo lokuvelisa, kukho abavelisi abaninzi abadumileyo ekhaya nakwamanye amazwe ngokuvelisa izixhobo zemifanekiso yezonyango, kuqukaI-LnkMedUkususela oko yasekwa, iLnkMed ibigxile kwicandelo lee-injectors ze-contrast agents ezinoxinzelelo oluphezulu. Iqela lobunjineli leLnkMed likhokelwa yiPh.D. enamava angaphezu kweminyaka elishumi kwaye ibandakanyeka kakhulu kuphando nophuhliso. Phantsi kwesikhokelo sakhe,I-CT single head injector,I-CT double head injector,I-MRI contrast agent injectorkunyeI-Angiography yoxinzelelo oluphezulu lwe-contrast agent injectorZenzelwe ezi mpawu zilandelayo: umzimba oqinileyo nomncinci, ujongano lokusebenza olulula nolukrelekrele, imisebenzi epheleleyo, ukhuseleko oluphezulu, kunye noyilo oluhlala ixesha elide. Singabonelela ngeesirinji kunye neetyhubhu ezihambelana nezo mpawu zidumileyo zee-injectors ze-CT, MRI, DSA Ngenxa yesimo sabo sengqondo esinyanisekileyo kunye namandla abo obuchwephesha, bonke abasebenzi be-LnkMed bayanimema ngokunyanisekileyo ukuba nize nihlole iimarike ezininzi kunye.