Ukuphucula ukunakekelwa kwesigulane kunye ne-AI-Based Attenuation Correction kwi-PET Imaging

Uphononongo olutsha olunesihloko esithi “Utilizing Pix-2-Pix GAN for Deep Learning-Based Whole-Body PSMA PET/CT Attenuation Correction” lusanda kupapashwa kuVolume 15 we-Oncotarget ngoMeyi 7, 2024.

Ukuvezwa kwemitha kwizifundo ezilandelelanayo ze-PET/CT kulandelelwaniso lwezigulane ze-oncology yinkxalabo. Kulo phando lwakutsha nje, iqela labaphandi elibandakanya uKevin C. Ma, uEsther Mena, uLiza Lindenberg, uNathan S. Lay, uPhillip Eclarinal, uDeborah E. Citrin, uPeter A. Pinto, uBradford J. Wood, uWilliam L. Dahut, uJames L. Gulley, uRavi A. Madan, uPeter L. Choyke, u-Ismail Baris Turkbey Institute kwi-National Cancer Institute, kunye no-Ismail Baris Turkbey. Impilo yazisa isixhobo sobukrelekrele bokwenziwa (AI). Esi sixhobo sijolise ekuveliseni imifanekiso ye-PET (AC-PET) elungisiweyo ye-attenuation kwimifanekiso ye-PET (NAC-PET) engeyiyo i-attenuation-corrected, enokunciphisa imfuneko ye-CT scans ye-dose ephantsi.

"Imifanekiso ye-PET eyenziwe nge-Ai inamandla ekliniki yokunciphisa imfuno yokulungiswa kokuthotywa kwe-CT scans ngelixa igcina iimpawu zobuninzi kunye nomgangatho womfanekiso kwizigulane ezinomhlaza we-prostate."

Iindlela: I-algorithm yokufunda nzulu esekelwe kwi-2D Pix-2-Pix ye-generative network adversarial network (GAN) architecture yaphuhliswa ngokusekelwe kwi-paired AC-PET kunye ne-NAC-PET imifanekiso. I-18F-DCFPyL PSMA (i-Prostate-specific membrane antigen) isifundo se-PET-CT sezigulane ze-302 ezinomdlavuza we-prostate zahlulwe zaba uqeqesho, ukuqinisekiswa, kunye namaqela okuvavanya (n 183, 60, kunye ne-59, ngokulandelanayo). Imodeli yaqeqeshwa kusetyenziswa amaqhinga amabini asemgangathweni: Ixabiso lokuFumana okuMgangatho (SUV) esekwe kunye neSUV-NYUL esekwe. Ukuskena ukusebenza okuthe tyaba kuye kwavavanywa kusetyenziswa impazamo yesikweri esiqhelekileyo (NMSE), ithetha impazamo epheleleyo (MAE), isalathiso sokufana kolwakhiwo (SSIM) kunye nencopho yomqondiso kwingxolo (PSNR). Ugqirha weyeza lenyukliya ngokulindelekileyo wenza uhlalutyo lwenqanaba lesilonda kwindawo enomdla. Iimpawu ze-SUV ziye zavavanywa kusetyenziswa i-intra-group coefficient (ICC), i-coefficient yokuphindaphinda (RC), kunye neemodeli zeziphumo ezixubeneyo ezihambelanayo.

Iziphumo:Kwiqela elizimeleyo lovavanyo, i-NMSE ephakathi, i-MAE, i-SSIM, kunye ne-PSNR yayiyi-13.26%, 3.59%, 0.891, kunye ne-26.82, ngokulandelanayo. I-ICC ye-SUVmax kunye ne-SUVmean yayiyi-0.88 kunye ne-0.89, ebonisa ulungelelwaniso oluqinileyo phakathi kwe-original kunye ne-AI-generated imaging imaging markers. Izinto ezifana nendawo yesilonda, ubuninzi (iiyunithi ze-Hounsfield), kunye nokunyuka kwe-lesion kufunyenwe ukuchaphazela impazamo ehambelanayo kwiimetriki ze-SUV ezenziweyo (zonke p <0.05).

"I-AC-PET eveliswa yi-Pix-2-Pix ye-GAN imodeli ibonisa iimethrikhi ze-SUV ezihambelana ngokusondeleyo nemifanekiso yasekuqaleni. Imifanekiso ye-PET eyenziwe nge-AI ibonisa amandla athembisayo ekliniki yokunciphisa imfuneko ye-CT scans yokulungiswa kokunciphisa ngelixa kugcinwa iimpawu zobuninzi kunye nomgangatho wesithombe."

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Njengoko sonke siyazi, ukuphuhliswa kwemboni yezobuchwephesha zonyango ayinakuhlukaniswa nokuphuhliswa koluhlu lwezixhobo zonyango - ii-injection ze-agent echaseneyo kunye nezinto ezixhasayo - ezisetyenziswa kakhulu kule ndawo. E-China, edume ngoshishino lwayo lokuvelisa, baninzi abavelisi abadumileyo ekhaya nakwamanye amazwe ngokuveliswa kwezixhobo zonyango zonyango, kuquka.LnkMed. Ukusukela ekusekweni kwayo, i-LnkMed ibigxile kwintsimi yee-ejenti zokuchasa ngoxinzelelo oluphezulu. Iqela lobunjineli be-LnkMed likhokelwa yi-Ph.D. uneminyaka engaphezu kweshumi yamava kwaye uzibandakanye nzulu kuphando nophuhliso. Phantsi kokhokelo lwakhe, iCT isitofu sentloko enye,CT isitofu sentloko kabini,Isitofu se-agent ye-MRI yokuchasana, kwayeI-Angiography yoxinzelelo oluphezulu lwe-ejenti yokuchasaziyilwe ngezi mpawu: umzimba owomeleleyo noxineneyo, ujongano olufanelekileyo nolukrelekrele lokusebenza, imisebenzi epheleleyo, ukhuseleko oluphezulu, kunye noyilo oluhlala ixesha elide. Sinokubonelela ngeesirinji kunye netyhubhu ehambelana nezo mpawu zidumileyo ze-CT, iMRI, ii-injection ze-DSA Ngesimo sabo sengqondo esinyanisekileyo kunye namandla obuchwephesha, bonke abasebenzi be-LnkMed bayakumema ngokunyanisekileyo ukuba uze uhlolisise iimarike ezininzi kunye.